The earliest cytologically identifiable precursor in the thrombocytic series. This cell is capable of endomitosis and lacks expression of hematopoieitic lineage markers (lin-negative). [ GOC:tfm GOC:dsd https://www.worldcat.org/search?q=bn%3A0721601464 ]
Synonyms: MkP megakaryoblast Meg-CFC megacaryocyte progenitor cell colony-forming unit-megakaryocyte CFU-Meg megakaryocytic progenitor cell megacaryoblast
Term information
- MESH:D055016
- FMA:84235
- BTO:0001164
- CALOHA:TS-0610
human_reference_atlas
Lineage negative is described here as CD2-negative, CD3-negative, CD4-negative, CD5-negative, CD8a-negative, CD14-negative, CD19-negative, CD20-negative, CD56-negative, Ly6g-negative, and Ter119-negative.
Term relations
- myeloid lineage restricted progenitor cell and capable of some endomitotic cell cycle and capable of some megakaryocyte differentiation and lacks_plasma_membrane_part some CD19 molecule and lacks_plasma_membrane_part some CD4 molecule and lacks_plasma_membrane_part some integrin alpha-M and lacks_plasma_membrane_part some CD3 epsilon and lacks_plasma_membrane_part some neural cell adhesion molecule 1 and lacks_plasma_membrane_part some CD2 molecule and lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1 and lacks_plasma_membrane_part some T-cell surface glycoprotein CD5 and lacks_plasma_membrane_part some CD14 molecule and lacks_plasma_membrane_part some lymphocyte antigen 6G and lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse)
- myeloid cell
- myeloid lineage restricted progenitor cell
- capable of some endomitotic cell cycle
- lacks_plasma_membrane_part some T-cell surface glycoprotein CD8 alpha chain
- lacks_plasma_membrane_part some CD4 molecule
- lacks_plasma_membrane_part some lymphocyte antigen 76 (mouse)
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- lacks_plasma_membrane_part some CD3 epsilon
- lacks_plasma_membrane_part some CD2 molecule
- lacks_plasma_membrane_part some integrin alpha-M
- capable of some megakaryocyte differentiation
- lacks_plasma_membrane_part some CD14 molecule
- lacks_plasma_membrane_part some neural cell adhesion molecule 1
- lacks_plasma_membrane_part some CD19 molecule
- develops from some megakaryocyte-erythroid progenitor cell
- lacks_plasma_membrane_part some T-cell surface glycoprotein CD5
- lacks_plasma_membrane_part some lymphocyte antigen 6G