Multilayered ectodermal region at the distal tip of a limb or fin bud necessary for the proper development of the underlying mesenchyme[MP,modified]. Along with the zone of polarizing activity, it is a crucial organizing region during limb development[WP]. [ MP:0001676 http://en.wikipedia.org/wiki/Apical_ectodermal_ridge ]
Synonyms: apical epidermal ridge
Term information
- AAO:0010760
- Wikipedia:Apical_ectodermal_ridge
- NCIT:C34109
- ZFA:0001702
- EMAPA:32744
- XAO:0004121
- TAO:0002146
pheno_slim
Term relations
- embryonic structure
- part of some paired limb/fin bud
- capable of some negative regulation of cartilage development
- part of some ectoderm
- developmentally induced by some mesenchyme
- capable of some regulation of mesenchymal cell proliferation
- produces some fibroblast growth factor 8