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p directly negatively regulates q iff p is immediately causally upstream of q, and p negatively regulates q.
directly negatively regulates (process to process)
http://purl.obolibrary.org/obo/ro/docs/causal-relations
http://purl.obolibrary.org/obo/RO_0002578
https://wiki.geneontology.org/Directly_negatively_regulates