The part of the pancreas that is part of the endocrine system and is made up of islet cells, which produce insulin, glucagon and somatostatin. [ http://amigo.geneontology.org/amigo/term/GO:GO http://orcid.org/0000-0002-6601-2165 ]
Synonyms: pars endocrina pancreatis endocrine pancreas
Term information
- CALOHA:TS-1302
- NCIT:C32509
- MA:0001582
- SCTID:361339003
- EFO:0002542
- EV:0100129
- BTO:0000650
- EMAPA:35305
- VHOG:0000049
- TAO:0001260
- ZFA:0001260
- FMA:16018
- Wikipedia:Islets_of_Langerhans
uberon_slim, efo_slim, pheno_slim, vertebrate_core, organ_slim, human_reference_atlas
The part of the pancreas that acts as an endocrine gland, consisting of the islets of Langerhans, which secrete insulin and other hormones. [TFD][VHOG]
The zebrafish endocrine pancreas is composed of small groups of islet cells that are distributed throughout the exocrine pancreas. The islet cells produce insulin, glucagon and somatostatin.[TAO]
In the hagfish and lampreys (our most primitive vertebrate species of today), the first sign of 'a new organ' is found as collections of endocrine cells around the area of the bile duct connection with the duodenum. These endocrine organs are composed of 99% beta cells and 1% somatostatin-producing delta cells. Compared to the more primitive protochordates (e.g. amphioxus), this represents a stage where all previously scattered insulin-producing cells of the intestinal tissue have now quantitatively migrated to found a new organ involved in sensing blood glucose rather than gut glucose. Only later in evolution, the beta cells are joined by exocrine tissue and alpha cells (exemplified by the rat-, rabbit- and elephant-fishes). Finally, from sharks and onwards in evolution, we have the islet PP-cell entering to complete the pancreas.[well established][VHOG]
Term relations
- compound organ component
- endoderm-derived structure
- cellular anatomical structure
- capable of some somatostatin secretion
- contributes to morphology of some pancreas
- part of some pancreas
- part of some endocrine system
- capable of some insulin secretion
- composed primarily of some islet of Langerhans
- capable of some glucagon secretion
- develops from some dorsal pancreatic bud