The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [ GOC:mtg_signaling_feb11 GOC:go_curators ]
Term information
goslim_chembl, goslim_generic, goslim_metagenomics, goslim_plant, goslim_candida, goslim_aspergillus
Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not.
signal transduction by protein phosphorylation
signal transduction by cis-phosphorylation
signal transduction by conformational transition
signaling cascade
signalling cascade
signal transduction by trans-phosphorylation
Term relations
- cellular process
- regulation of cellular process
- part of some signaling
- part of some cellular response to stimulus
- part of some cell communication