A specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes. [ http://zfin.org/ZDB-PUB-070221-3 http://purl.obolibrary.org/obo/CL_curator ]
Term information
- CL:0000092
- TAO:0009047
cell_slim
Morphology: Highly vesicular; markers: Surface: RANK, cFMS (MCSF receptor); Secreted: cathepsin K and TRAP (tartate resistant acid phosphatase); transcription factors: PU.1, cFOS, MITF, NFkB (p52); role or process: tissue remodelling: bone resorption; lineage: hematopoietic, myeloid.
Term relations
- cell
- mesoderm-derived structure
- existence starts during or after some unknown
- develops from some monocyte