Either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible. [ http://www.informatics.jax.org/accession/anna http://dx.doi.org/10.1111/j.1432-0436.2006.00088.x ]
Synonyms: submandibular salivary gland mandibular gland mandibular salivary gland
Term information
- EV:0100061
- CALOHA:TS-0988
- BTO:0001316
- GAID:942
- VHOG:0000364
- NCIT:C12233
- FMA:55093
- Wikipedia:Submandibular_gland
- MA:0001589
- UMLS:C0038556 (ncithesaurus:Submandibular_Gland)
- MESH:D013363
- SCTID:181235001
- EMAPA:18812
- EFO:0001387
uberon_slim, efo_slim, pheno_slim
The submandibular is the first major salivary gland to develop in the embryo, followed by the neighbouring sublingual and then the parotid.[PMID:17336109]
Either of two major salivary glands situated in the neck near the lower edge of each side of the mandible and emptying into the submandibular duct. [TFD][VHOG]
The most common oral glands in mammals are the salivary glands. There are usually three primary pairs of salivary glands, named for their approximate positions: mandibular (submandibular or submaxillary), sublingual, and parotid.[well established][VHOG]
In humans, they account for 70% of the salivary volume and weigh about 15 grams. [WP,unvetted]
in mice, submandibular gland development initiates as a thickening of the oral epithelium; around E12 an initial (single) epithelial bud on a stalk grows into a condensing neural crest-derived mesenchyme; clefts in the epithelium result in 3-5 epithelial buds at E13.5, and branching morphogenesis occurs with continued proliferation, successive rounds of cleft formation, duct elongation, and duct lumen formation, so that by E14 the gland is highly branched (multi-lobed); functional differentiation, with the appearance of proacinar cells and secretory products begins after E15 and continues to birth; acinar differentiation continues postnatally with final differentiation of the granular convoluted tubules at puberty[MGI:anna]
In mouse, multilobed and lobulated, on the ventral midline of the neck
The term submandibular as used in humans, is incorrect due the difference in topography of these structures[http://www.avdc.org]
Term relations
- major salivary gland
- develops from some submandibular gland primordium
- only in taxon some Amniota
- in lateral side of some lower jaw region