An intracellular signal transduction pathway that starts with the activation of a SMAD protein, leading to the formation of a complex with co-SMADs, which translocates to the nucleus, where it regulates transcription of specific target genes. [ GOC:BHF ]
This is just here as a test because I lose it
Term information
comment
Note that the upstream receptor and its ligand regulate the pathway (and are not part of the SMAD pathway), since it is an intracellular signaling pathway.