post-translational protein modification
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The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome. [ GOC:jsg ]
Synonyms: posttranslational amino acid modification posttranslational modification PTM posttranslational protein modification post-translational modification post-translational amino acid modification
Term information
This term should only be used to annotate a protein modification process that occurs after the protein has been released from the ribosome, and is therefore strictly post-translational. Modification of a free protein (one not attached to a ribosome) and modification of a C-terminal residue are post-translational processes. Some protein modifications occur while the protein is still in the ribosome but before translation has been completed; these modification processes are considered co-translational and should not be annotated using this term.