ATPase-coupled transmembrane transporter activity
Go to external page http://purl.obolibrary.org/obo/GO_0042626
Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. [ https://www.worldcat.org/search?q=bn%3A0815340729 GOC:mtg_transport ]
Synonyms: ATP-coupled transmembrane transporter activity ATP-dependent transmembrane transporter activity ATPase activity, coupled to transmembrane movement of substances
Term information
- Reactome:R-HSA-9750546 (ABCC4 transports TPMP substrates from cytosol to extracellular region)
- Reactome:R-HSA-9753278 (ABCC2,ABCG2 transport APAP-GlcA, APAP-SO3)
- Reactome:R-HSA-9750617 (ABCC5 transports TPMP substrates from cytosol to extracellular region)
- Reactome:R-HSA-2161538 (abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate)
- Reactome:R-HSA-1467457 (ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region)
- Reactome:R-HSA-9794572 (ABCG2 transports Cipro from hepatic cell to extracellular space)
- Reactome:R-HSA-9759461 (ABCB1 transports PREDN,PREDL out of hepatic cells)
- Reactome:R-HSA-2161506 (abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate)
- Reactome:R-HSA-9753284 (ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region)
- Reactome:R-HSA-9033499 (PEX1:PEX6:PEX26:ZFAND6 dissociates Ub:PEX5L and PEX7 from PEX14:PEX13:PEX2:PEX10:PEX12 and translocates PEX5L and PEX7 from the peroxisomal membrane to the cytosol)
- Reactome:R-HSA-9753283 (ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3)
- Reactome:R-HSA-9794120 (ABCG2 transports Cipro from intestinal cell to extracellular space)
- Reactome:R-HSA-9759454 (ABCB1 transports PREDN,PREDL out of kidney cells)
- Reactome:R-HSA-9033505 (PEX1:PEX6:PEX26:ZFAND6:Ub:PEX5S,L:PEX14:PEX13:PEX2:PEX10:PEX12 dissociates yielding cytosolic Ub:PEX5S,L and membrane PEX14:PEX13:PEX2:PEX10:PEX12)
- Reactome:R-HSA-9659680 (ABCB1 transports xenobiotics out of the cell)
- EC:7.2.2.-
P-P-bond-hydrolysis-driven transporter
ATPase activity, coupled to movement of substances
P-P-bond-hydrolysis-driven transmembrane transporter activity
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
https://github.com/geneontology/go-ontology/issues/17373
https://github.com/geneontology/go-ontology/issues/14642
https://github.com/geneontology/go-ontology/issues/19965