intracellularly ATP-gated chloride channel activity
Go to external page http://purl.obolibrary.org/obo/GO_0005260
Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. [ http://www.ncbi.nlm.nih.gov/pubmed/9922375 http://www.ncbi.nlm.nih.gov/pubmed/24727426 ]
Synonyms: CFTR
Term information
This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator).