Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. [ https://www.worldcat.org/search?q=bn%3A0198547684 ]
Synonyms: ERK activator kinase activity MAPK activator activity MAPKK activity
Term information
- MetaCyc:2.7.12.2-RXN
- Reactome:R-HSA-1247960 (Activation of p38 MAPK)
- Reactome:R-HSA-448951 (Activation of p38 alpha/beta MAPK)
- EC:2.7.12.2
- Reactome:R-HSA-450333 (Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3)
- Reactome:R-HSA-3238999 (Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5)
- Reactome:R-HSA-5218804 (p38 MAPK activation by VEGFR)
mitogen-activated protein kinase kinase activity
ATP:protein phosphotransferase (MAPKKK-activated) activity
MKK2
MKK4
MAPKK
MAPKK1
MKK
MKK6
MKK7
MAP2K
STK27
MEK1
MEK2
MAP kinase or ERK kinase activity