Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile. [ GOC:mah https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE ]
Synonyms: thiol endopeptidase activity
This is just here as a test because I lose it
Term information
database
cross reference
- Reactome:R-HSA-201631 (Caspase-mediated cleavage of Desmoglein 3)
- Reactome:R-HSA-201637 (Caspase-mediated cleavage of plectin-1)
- Reactome:R-HSA-9694377 (pp1a cleaves itself)
- Reactome:R-HSA-9012556 (IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37)
- Reactome:R-HSA-2130349 (Generation of CLIP from lip10)
- Reactome:R-HSA-350319 (Caspase mediated cleavage of vimentin at IDVD (259))
- Reactome:R-HSA-201595 (Caspase-mediated cleavage of plakophilin-1)
- Reactome:R-HSA-202966 (Caspase mediated cleavage of HIP-55)
- Reactome:R-HSA-202917 (Caspase-mediated cleavage of Desmoglein 1)
- Reactome:R-HSA-9684321 (nsp3 cleaves nsp1-4)
- Reactome:R-HSA-933532 (Processing of caspases)
- Reactome:R-HSA-350158 (LGMN degrades GC)
- Reactome:R-HSA-2562564 (Caspase-8 processing within TLR4 complex)
- Reactome:R-HSA-9694338 (nsp1-4 cleaves itself)
- Reactome:R-HSA-9729741 (SARS-CoV-2 3CLpro dimer cleaves NLRP12)
- Reactome:R-HSA-9694551 (3CLp cleaves nsp6-11)
- Reactome:R-HSA-418846 (Caspase cleavage of UNC5A)
- Reactome:R-HSA-114261 (Cleavage of Procaspase-7 by the apoptosome)
- Reactome:R-HSA-202939 (Caspase-mediated cleavage of E-Cadherin)
- Reactome:R-HSA-9694732 (3CLp cleaves pp1ab)
- Reactome:R-HSA-202960 (Caspase mediated cleavage of C-IAP1)
- Reactome:R-HSA-9684351 (pp1a cleaves itself)
- Reactome:R-HSA-9684336 (nsp1-4 cleaves itself)
- Reactome:R-HSA-9647632 (CASP3 cleaves GSDME)
- Reactome:R-HSA-5357828 (RIPK1 is cleaved by CASP8)
- Reactome:R-HSA-9694441 (3CLp cleaves pp1a)
- Reactome:R-HSA-211190 (Caspase 3-mediated cleavage of DFF45 (117))
- Reactome:R-HSA-2130336 (Initial proteolyis of Ii by aspartic proteases to lip22)
- Reactome:R-HSA-351901 (Caspase-mediated cleavage of MST3)
- Reactome:R-HSA-1678920 (TLR processing at low pH)
- Reactome:R-HSA-1236948 (Antigen processing by cathepsin S in endosoytic vesicle)
- Reactome:R-HSA-201639 (Caspase-mediated cleavage of GAS2)
- Reactome:R-HSA-351936 (Caspase-mediated cleavage of claspin)
- Reactome:R-HSA-9694601 (nsp3-4 cleaves itself)
- Reactome:R-HSA-351871 (Caspase-mediated cleavage of Z0-2)
- Reactome:R-HSA-201611 (Caspase-mediated cleavage of Rock-1)
- Reactome:R-HSA-201603 (Caspase-mediated cleavage of PKC theta)
- Reactome:R-HSA-448703 (Interleukin-1 family precursors are cleaved by caspase-1)
- Reactome:R-HSA-351877 (Caspase-mediated cleavage of Desmoglein 2)
- Reactome:R-HSA-350318 (Caspase-mediated cleavage of vimentin at TNLD (429))
- Reactome:R-HSA-6814387 (CASP14 cleaves filaggrin)
- Reactome:R-HSA-9647999 (RCE1 cleaves S-Farn proRAS proteins)
- Reactome:R-HSA-351894 (Caspase mediated cleavage of BAP31)
- Reactome:R-HSA-9647680 (CASP1 cleaves GSDMD)
- Reactome:R-HSA-202947 (Caspase mediated cleavage of APC)
- EC:3.4.22.-
- Reactome:R-HSA-9684352 (nsp3-4 cleaves itself)
- Reactome:R-HSA-418852 (Caspase cleavage of UNC5B)
- Reactome:R-HSA-9697750 (RIPK1 is cleaved by CASP8:FLIP(L))
- Reactome:R-HSA-114252 (Cleavage of Procaspase-3 by the apoptosome)
- Reactome:R-HSA-202967 (Caspase mediated cleavage of alpha-II-Fodrin)
- Reactome:R-HSA-352268 (Cleavage of Satb1)
- Reactome:R-HSA-139952 (Caspase-8 processing in the DISC)
- Reactome:R-HSA-5634228 (TRAF1 is cleaved by caspases)
- Reactome:R-HSA-201640 (Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha)
- Reactome:R-HSA-9686088 (CASP3 cleaves GSDMD)
- Reactome:R-HSA-211186 (Cleavage of DFF45 (224) by caspase-3)
- Reactome:R-HSA-9686930 (RIPK3 is cleaved by CASP8)
- Reactome:R-HSA-1678981 (TLR9 processing at neutral pH)
- Reactome:R-HSA-2130706 (MHC class II antigen processing)
- Reactome:R-HSA-211651 (Cleavage of PAK-2 at 212)
- Reactome:R-HSA-9729704 (SARS-CoV-2 3CLpro dimer cleaves TAB1)
- Reactome:R-HSA-2130504 (Cleavage of lip22 to lip10)
- Reactome:R-HSA-5681987 (LC3 is cleaved by ATG4)
- Reactome:R-HSA-9710101 (CASP4, CASP5 cleave GSDMD)
- Reactome:R-HSA-201622 (Caspase-mediated cleavage of gelsolin)
- Reactome:R-HSA-351876 (Caspase-mediated cleavage of occludin)
- Reactome:R-HSA-139898 (Caspase-8 activates BID by cleavage)
- Reactome:R-HSA-212552 (Caspase 3-mediated cleavage of PKC delta)
- Reactome:R-HSA-201629 (Caspase-mediated cleavage of Tau)
- Reactome:R-HSA-418845 (Activation of caspase-3)
- Reactome:R-HSA-201608 (Caspase-mediated cleavage of alpha adducin)
- Reactome:R-HSA-5682377 (LC3 de-lipidation by ATG4)
- Reactome:R-HSA-351849 (Caspase-mediated cleavage of Etk)
- Reactome:R-HSA-264865 (Caspase-mediated cleavage of Lamin A)
- Reactome:R-HSA-2028692 (Cleavage of p-STK4 (p-MST1) by caspase 3)
- Reactome:R-HSA-9729730 (SARS-CoV-2 nsp3 cleaves IRF3)
- Reactome:R-HSA-9684309 (3CLp cleaves nsp6-11)
- Reactome:R-HSA-9693929 (RIPK1 variant is not cleaved by CASP8)
- Reactome:R-HSA-201628 (Caspase-mediated cleavage of vimentin at DSVD (85))
- Reactome:R-HSA-350651 (Caspase-mediated cleavage of MASK)
- Reactome:R-HSA-9684273 (3CLp cleaves pp1a)
- Reactome:R-HSA-2028697 (Cleavage of p-STK3 (p-MST2) by caspase 3)
- Reactome:R-HSA-3465448 (Caspase-8 and FLIP(L) processing at DISC)
- Reactome:R-HSA-114259 (Cleavage of Procaspase9 to caspase9)
- Reactome:R-HSA-264871 (Caspase-mediated cleavage of Lamin B1)
- Reactome:R-HSA-201634 (Caspase-mediated cleavage of FADK 1)
- Reactome:R-HSA-201630 (Caspase-mediated cleavage of Acinus)
- Reactome:R-HSA-201636 (Caspase-mediated cleavage of Desmoplakin)
- Reactome:R-HSA-9684340 (3CLp cleaves pp1ab)
- Reactome:R-HSA-351913 (Caspase-mediated cleavage of TJP1)
- Reactome:R-HSA-202969 (Caspase mediated cleavage of beta-catenin)
- Reactome:R-HSA-9013895 (Caspase-8 processing within TLR3 complex)
- Reactome:R-HSA-9694625 (nsp3 cleaves nsp1-4)
- Reactome:R-HSA-5660663 (Caspase-8 cleaves IL1B precursor)
- Reactome:R-HSA-9603534 (Unknown caspase cleaves NTRK3)