Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. [ GOC:mah https://enzyme.expasy.org/EC/2.7.7.48 GOC:pf ]
Synonyms: RdRP activity RNA-dependent RNA replicase activity RNA nucleotidyltransferase (RNA-directed) activity RNA-directed 5'-3' RNA polymerase activity RNA-directed RNA polymerase activity
Term information
- Reactome:R-HSA-9694277 (nsp8 generates RNA primers)
- Reactome:R-HSA-168301 (Elongation, Polyadenylation and Termination)
- Reactome:R-HSA-9681840 (RTC synthesizes SARS-CoV-1 plus strand genomic RNA)
- Reactome:R-HSA-9682563 (nsp12 misincorporates a nucleotide in nascent RNA minus strand)
- Reactome:R-HSA-192832 (Initiation of cRNA Synthesis)
- Reactome:R-HSA-192916 (Initiation of vRNA Synthesis)
- MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN
- Reactome:R-HSA-9694549 (RTC completes synthesis of the minus strand genomic RNA complement)
- Reactome:R-HSA-168280 (Priming and Initiation of Transcription)
- Reactome:R-HSA-9694605 (nsp12 synthesizes minus strand SARS-CoV-2 genomic RNA complement)
- Reactome:R-HSA-9694792 (nsp12 misincorporates a nucleotide in nascent RNA minus strand)
- Reactome:R-HSA-9694581 (RTC synthesizes SARS-CoV-2 plus strand genomic RNA)
- Reactome:R-HSA-9681651 (nsp8 generates RNA primers)
- EC:2.7.7.48
- Reactome:R-HSA-192624 (cRNA Extension)
- Reactome:R-HSA-9694506 (Synthesis of SARS-CoV-2 plus strand subgenomic mRNAs)
- Reactome:R-HSA-9685681 (Synthesis of SARS-CoV-1 plus strand subgenomic mRNAs)
- Reactome:R-HSA-9694344 (Synthesis of SARS-CoV-2 minus strand subgenomic mRNAs by template switching)
- Reactome:R-HSA-9682465 (RTC completes synthesis of the minus strand genomic RNA complement)
- Reactome:R-HSA-9685639 (Synthesis of SARS-CoV-1 minus strand subgenomic mRNAs by template switching)
- Reactome:R-HSA-192851 (vRNA Extension)
- Reactome:R-HSA-9681674 (nsp12 synthesizes minus strand SARS-CoV-1 genomic RNA complement)