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DNA-binding transcription factor activity

Go to external page http://purl.obolibrary.org/obo/GO_0003700

A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [ GOC:txnOH-2018 ]

Synonyms: DNA binding transcription factor activity sequence-specific DNA binding transcription factor activity gene-specific transcription factor activity

This is just here as a test because I lose it

Term information

Subsets

goslim_chembl, goslim_metagenomics, goslim_drosophila, goslim_agr, goslim_mouse, goslim_plant, goslim_yeast, goslim_candida

comment

Usage guidance: Most DNA-binding transcription factors do not have enzymatic activity. The presence of specific DNA-binding domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing zinc fingers, Myb/SANT and ARID domains, since only a subset of proteins containing these domains directly and selectively bind to regulatory DNA motifs in cis-regulatory regions.

creation date

2010-10-21T04:37:54Z

has broad synonym

transcription factor activity

nucleic acid binding transcription factor activity

has narrow synonym

transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding

metal ion regulated sequence-specific DNA binding transcription factor activity

metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity

bacterial-type DNA binding transcription factor activity

transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding

bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity

sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity

transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding

bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding

bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity

bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding

transcription factor activity, metal ion regulated sequence-specific DNA binding

has alternative id

GO:0001199

GO:0001131

GO:0000130

GO:0001130

GO:0001151

GO:0001071

GO:0001204

has obo namespace

molecular_function

id

GO:0003700

term tracker item

https://github.com/geneontology/go-ontology/issues/15704

https://github.com/geneontology/go-ontology/issues/20253

https://github.com/geneontology/go-ontology/issues/16534