increased minichromosome loss upon segregation during vegetative growth
Go to external page http://purl.obolibrary.org/obo/FYPO_0001861
A cell phenotype in which minichromosomes are lost due to abnormal mitotic sister chromatid segregation at a higher frequency than normal. [ https://www.pombase.org/gene/mah ]
Synonyms: increased plasmid loss upon segregation during mitotic cell cycle
Term information
Use this term if the assay to detect minichromosome loss can distinguish a segregation defect from a replication defect (e.g. by microscopy). Note that in budding yeast, increased plasmid loss is often called a minichromosome maintenance defect, because "minichromosome" is roughly synonymous with an autonomously replicated and segregated plasmid in that organism. In fission yeast, a minichromosome is a large portion of a chromosome, usually about half of chromosome 3, that replicates and segregates autonomously. For smaller autonomously replicating and segregating constructs, consider 'increased plasmid loss' (FYPO:0000786).