Goblet cells reside throughout the length of the small and large intestine and are responsible for the production and maintenance of the protective mucus blanket by synthesizing and secreting high-molecular-weight glycoproteins known as mucins. Human intestinal goblet cells secrete the MUC2 mucin, as well as a number of typical mucus components: CLCA1, FCGBP, AGR2, ZG16, and TFF3. [ http://www.ncbi.nlm.nih.gov/pubmed/1996606 http://www.ncbi.nlm.nih.gov/pubmed/24942678 ]