A lymphoid progenitor cell that is committed to the natural killer cell lineage, expressing CD122 (IL-15) receptor, but lacking many of the phenotypic characteristics of later stages of natural killer cell development such as expression of NK activating and inhibitory molecules. In human this cell has the phenotype CD34-positive, CD45RA-positive, CD10-positive, CD117-negative, and CD161 negative. [ http://www.ncbi.nlm.nih.gov/pubmed/15766674 http://www.ncbi.nlm.nih.gov/pubmed/15032583 GOC:add http://www.ncbi.nlm.nih.gov/pubmed/12457618 http://www.ncbi.nlm.nih.gov/pubmed/11532393 GOC:pam http://purl.obolibrary.org/obo/go/references/0000031 ]
Synonyms: pro-natural killer cell NKP natural killer cell progenitor
Term information
Term relations
- lymphoid lineage restricted progenitor cell and lacks_plasma_membrane_part some KLRB1-like protein and lacks_plasma_membrane_part some mast/stem cell growth factor receptor and has plasma membrane part some CD34 molecule and has plasma membrane part some receptor-type tyrosine-protein phosphatase C isoform CD45RA and has plasma membrane part some interleukin-2 receptor subunit beta and has plasma membrane part some neprilysin
- lymphoid lineage restricted progenitor cell
- protein-containing material entity
- has part some interleukin-2 receptor subunit beta
- has part some receptor-type tyrosine-protein phosphatase C isoform CD45RA
- has part some CD34 molecule
- has part some neprilysin
- develops from some common lymphoid progenitor