Langerhans cell is a conventional dendritic cell that has plasma membrane part CD207. A Langerhans cell is a stellate dendritic cell of myeloid origin, that appears clear on light microscopy and has a dark-staining, indented nucleus and characteristic inclusions (Birbeck granules) in the cytoplasm; Langerhans cells are found principally in the stratum spinosum of the epidermis, but they also occur in other stratified epithelia and have been identified in the lung, lymph nodes, spleen, and thymus. [ https://www.worldcat.org/search?q=bn%3A0721601464 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2346585 https://www.worldcat.org/search?q=bn%3A0781735149 http://purl.obolibrary.org/obo/go/references/0000031 GOC:add GOC:amm http://www.ncbi.nlm.nih.gov/pubmed/17850486 ]
Synonyms: LC
Term information
- FMA:63072
- CALOHA:TS-2375
- BTO:0000705
- MESH:D007801
human_reference_atlas
Originally described in the dendritic cell ontology (DC_CL:0000021 )(PMID:19243617). These cells are also CD1a-high, CD14-negative, CD207-positive (langerin), CD324-positive (E-cadherin), and DCIR-positive. They reside in the epidermis.
Term relations
- conventional dendritic cell and has plasma membrane part some C-type lectin domain family 4 member K and capable of some regulation of type 2 immune response
- myeloid leukocyte
- conventional dendritic cell
- has part some C-type lectin domain family 4 member K
- develops from some myeloid cell