An epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell. [ MESH:D015603 GOC:dsd http://www.ncbi.nlm.nih.gov/pubmed/15582983 http://www.ncbi.nlm.nih.gov/pubmed/15749908 http://www.ncbi.nlm.nih.gov/pubmed/19727116 http://en.wikipedia.org/wiki/Keratinocyte ]
Synonyms: malpighian cell keratinized cell of epidermis
Term information
- FMA:62879
- CALOHA:TS-0500
- BTO:0000667
human_reference_atlas
Keratinocytes are reportedly CDw210a-negative, CDw210b-positive, CD281-positive, CD282-positive, CD285-positive, IL22Ra1-positive, Human keratinocytes are reportedly capable of secreting BD-2, BD-3, hCAP-18, CXCL1, CXCL5, CXCL8, elafin, MMP-3, NGAL, PDGF-A, S100A7, S100A8, and S100A9. Transcription factors: STAT3-positive.
Term relations
- keratinizing barrier epithelial cell
- epidermal cell
- part of some skin epidermis
- capable of some antimicrobial peptide production
- capable of some antimicrobial peptide secretion
- capable of some positive regulation of neutrophil chemotaxis