A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation. [ MESH:D001792 http://www.ncbi.nlm.nih.gov/pubmed/16987572 GOC:add http://www.ncbi.nlm.nih.gov/pubmed/11110672 http://www.ncbi.nlm.nih.gov/pubmed/17479180 http://www.ncbi.nlm.nih.gov/pubmed/20414831 http://en.wikipedia.org/wiki/Platelet http://www.ncbi.nlm.nih.gov/pubmed/17204662 GOC:dsd GOC:tfm ]
Synonyms: blood platelet enucleate thrombocyte anucleate thrombocyte
Term information
- FMA:62851
- CALOHA:TS-0803
- BTO:0000132
blood_and_immune_upper_slim, human_reference_atlas
Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF.
Term relations
- serotonin secreting cell
- blood cell
- myeloid cell
- anucleate cell
- bearer of some discoid
- capable of part of some blood coagulation
- develops from some megakaryocyte