A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs. [ http://www.ncbi.nlm.nih.gov/pubmed/16923606 http://www.ncbi.nlm.nih.gov/pubmed/17986482 http://www.ncbi.nlm.nih.gov/pubmed/19960544 GOC:dsd http://flybase.org/reports/ma.htm http://www.copewithcytokines.de/cope.cgi?key=mesenchymal%20stem%20cells http://www.ncbi.nlm.nih.gov/pubmed/10102814 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613570 http://en.wikipedia.org/wiki/Mesenchymal_stem_cell ]
Term information
- FMA:70546
- BTO:0002625
- BTO:0003298
Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.
bone marrow stromal cells
BMSC
colony-forming unit-fibroblast
marrow stromal cells
mesenchymal stem cell
mesenchymal progenitor cells
mesenchymal stromal cells
mesenchymal precursor cell
stem cells, mesenchymal
CFU-F
mesenchymal stromal cell
MSC