A tissue-resident macrophage of the reticuloendothelial system found on the luminal surface of the hepatic sinusoids involved in erythrocyte clearance. Markers include F4/80+, CD11b-low, CD68-positive, sialoadhesin-positive, CD163/SRCR-positive. Irregular, with long processes including lamellipodia extending into the sinusoid lumen, have flattened nucleus with cytoplasm containing characteristic invaginations of the plasma membrane (vermiform bodies); lie within the sinusoid lumen attached to the endothelial surface; derived from the bone marrow, form a major part of the body's mononuclear phagocyte system. [ https://www.worldcat.org/search?q=bn%3A0517223651 MESH:D007728 GOC:add http://www.ncbi.nlm.nih.gov/pubmed/17105582 GOC:tfm http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/15771589 ]
Synonyms: von Kupffer cell stellate cell of von Kupffer littoral cell of hepatic sinusoid macrophagocytus stellatus liver macrophage hepatic macrophage
Term information
- FMA:14656
- BTO:0000685
human_reference_atlas
Markers: Mouse: F4/80+, CD11b-low, CD68+, sialoadhesin+, CD163/SRCR+; role or process: immune, antigen-presentation, clearance of senescent erythrocytes, iron metabolism. Kupffer cells are also reportedly C3aR-positive, CD14-low, CD54-positive, CD88-positive, and CD284-positive. They are also capable of producing IL-1, IL-6, TNF-alpha, nitric oxide, PGD2, PGE2, PGF2alpha, and TXA2.
Term relations
- tissue-resident macrophage and located in some hepatic sinusoid and has plasma membrane part some adhesion G protein-coupled receptor E1 and has plasma membrane part some scavenger receptor cysteine-rich type 1 protein M130 and has plasma membrane part some macrosialin and capable of some erythrocyte clearance and has low plasma membrane amount some integrin alpha-M