A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001) [ NCIT:C3247 ]
Synonyms: Myelodysplastic Syndromes oligoblastic leukemia MDS, unclassifiable preleukemia myelodysplastic syndrome, somatic myelodysplastic neoplasm dysmyelopoietic syndrome myelodysplasia hematopoeitic - myelodysplastic syndrome (MDS) smoldering leukemia myelodysplastic syndrome, unclassifiable myelodysplastic syndromes MDS-U smouldering leukaemia myelodysplastic syndrome/neoplasm myelodysplastic syndrome MDS oligoblastic leukaemia
Term information
- NCIT:C3247 (MONDO:equivalentTo)
- ICDO:9989/3 (NCIT:C3247)
- MEDGEN:483005 (MONDO:equivalentTo)
- NANDO:2200019 (https://orcid.org/0000-0003-0011-764X)
- NANDO:2100003 (https://orcid.org/0000-0003-0011-764X)
- MedDRA:10028532 (Orphanet:52688/e)
- OMIM:614286 (Orphanet:52688/e)
- ICD9:238.7 (DOID:0050908)
- Orphanet:52688 (OMIM:614286)
- DOID:0050908 (MONDO:equivalentTo)
- GARD:7132 (MONDO:GARD)
- NORD:1480 (MONDO:NORD)
- SCTID:109995007 (MONDO:equivalentTo)
- UMLS:C3463824 (MONDO:equivalentTo)
- EFO:0000198 (MONDO:equivalentTo)
- ICD9:238.75 (MONDO:i2s)
- ONCOTREE:MDS (MONDO:equivalentTo)
gard_rare, otar, disease_grouping, rare, nord_rare, ordo_group_of_disorders
https://github.com/monarch-initiative/mondo/issues/5268
https://github.com/monarch-initiative/mondo/issues/4521
https://omim.org/entry/614286
http://www.orpha.net/ORDO/Orphanet_52688
http://linkedlifedata.com/resource/umls/id/C3463824
http://purl.obolibrary.org/obo/NCIT_C3247
http://purl.obolibrary.org/obo/DOID_0050908
http://identifiers.org/snomedct/109995007
http://identifiers.org/medgen/483005