A decreased level of serum immunoglobulins. It may be inherited or acquired. It is caused by decreased or inefficient production of immunoglobulins from B cells or by a decrease in the numbers of B cells themselves. Low levels of immunoglobulins will affect the immune system's ability to combat bacterial infection. Supplementation of immunoglobulins is needed to prevent worsening outcomes. [ NCIT:P378 ]
Synonyms: IGHM agammaglobulinemia mu heavy chain deficiency hypogammaglobulinemia
Term information
- MEDGEN:168 (MONDO:equivalentTo)
- OMIMPS:601495 (https://orcid.org/0000-0002-6601-2165)
- ICD9:279.00 (DOID:2583)
- MedDRA:10001471 (Orphanet:183669/e)
- MESH:D000361 (Orphanet:183669/e)
- Orphanet:183669 (MONDO:equivalentTo)
- GARD:20320 (MONDO:GARD)
- DOID:2583 (MONDO:equivalentTo)
- UMLS:C0001768 (MONDO:equivalentTo)
gard_rare, otar, disease_grouping, rare, clingen, ordo_group_of_disorders
http://identifiers.org/mesh/D000361
http://linkedlifedata.com/resource/umls/id/C0001768
http://identifiers.org/medgen/168
https://omim.org/phenotypicSeries/PS601495
http://www.orpha.net/ORDO/Orphanet_183669
http://purl.obolibrary.org/obo/DOID_2583