Acute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11). [ Orphanet:514 ]
Synonyms: leukemia, monocytic, malignant AML M5 acute monocytic leukemia, morphology (morphologic abnormality) acute monoblastic leukaemia and acute monocytic leukaemia acute monocytic leukemia (FAB M5B) acute monocytic leukemia (FAB M5b) acute monocytic leukemia acute monocytic leukemia, FAB M5 acute monocytic leukaemia without mention of remission acute monoblastic leukemia and acute monocytic leukemia acute monocytic leukemia, morphology acute monocytic leukaemia (FAB M5b) acute monocytic leukaemia (FAB M5B) monocytic leukemia, acute acute monocytic leukemia without mention of remission
Term information
- EFO:0000221 (MONDO:equivalentTo)
- ONCOTREE:AMOL (MONDO:equivalentTo)
- MESH:D007948 (Orphanet:514/e)
- CSP:2004-2820 (DOID:8864)
- icd11.foundation:517546180 (https://orcid.org/0000-0002-4142-7153)
- OMIM:151380 (MONDO:equivalentTo)
- DOID:8864 (MONDO:equivalentTo)
- SCTID:413441006 (MONDO:equivalentTo)
- MEDGEN:7319 (MONDO:equivalentTo)
- ICD9:206.0 (EFO:0000221)
- MedDRA:10000871 (Orphanet:514/e)
- MedDRA:10059439 (Orphanet:514/e)
- GARD:525 (MONDO:GARD)
- NANDO:2200009 (https://orcid.org/0000-0003-0011-764X)
- NANDO:2200008 (https://orcid.org/0000-0003-0011-764X)
- ICDO:9891/3 (NCIT:C4861)
- NCIT:C4861 (MONDO:equivalentTo)
- Orphanet:514 (MONDO:equivalentTo)
- UMLS:C0023465 (MONDO:equivalentTo)
ordo_disorder, gard_rare, otar, rare, nord_rare, orphanet_rare
http://identifiers.org/snomedct/413441006
http://purl.obolibrary.org/obo/NCIT_C4861
http://www.orpha.net/ORDO/Orphanet_514
http://purl.obolibrary.org/obo/DOID_8864
http://identifiers.org/medgen/7319
https://omim.org/entry/151380
http://identifiers.org/mesh/D007948
http://linkedlifedata.com/resource/umls/id/C0023465
leukemia, acute monocytic
acute monoblastic leukaemia
acute monoblastic/monocytic leukaemia
acute myeloblastic leukemia type 5
acute myeloblastic leukaemia type 5
acute monoblastic/monocytic leukemia
AML-M5
acute monoblastic leukemia