A group of rare bone development disorders characterized by an array of abnormalities affecting the eyes, forehead, and nose, and linked to midfacial dysraphia. The clinical picture is highly variable, but the major findings include hypertelorism, a broad nasal root, a large and bifid nasal tip, and widow's peak. Occasionally, abnormalities can include accessory nasal tags, cleft lip, ocular abnormalities (coloboma, cataract, microphthalmia), conductive hearing loss, basal encephalocele and/or agenesis of the corpus callosum. Intellectual deficit is rare and more likely to occur in cases where hypertelorism is severe or where there is extra-cranial involvement. [ Orphanet:250 ]
Synonyms: median cleft face syndrome
Term information
- GARD:2392 (Orphanet:250)
- SCTID:86610004 (MONDO:equivalentTo)
- DOID:0081044 (MONDO:equivalentTo)
- Orphanet:250 (MONDO:equivalentTo)
- UMLS:C1876203 (Orphanet:250/e)
- OMIMPS:136760 (MONDO:equivalentTo)
- NORD:1165 (MONDO:NORD)
- MESH:C538065 (Orphanet:250/e)
gard_rare, disease_grouping, rare, nord_rare, orphanet_rare, ordo_group_of_disorders
http://identifiers.org/mesh/C538065
http://www.orpha.net/ORDO/Orphanet_250
https://omim.org/phenotypicSeries/PS136760
http://linkedlifedata.com/resource/umls/id/C1876203
http://identifiers.org/snomedct/86610004
http://purl.obolibrary.org/obo/DOID_0081044