A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression. [ NCIT:P378 ]
Synonyms: Parkinson's disease Parkinson disease paralysis agitans
Term information
- DOID:14330 (MONDO:equivalentTo)
- UMLS:C0030567 (NCIT:C26845)
- MESH:D010300 (MONDO:equivalentTo)
- NIFSTD:birnlex_2098 (EFO:0002508)
- ICD9:332.0 (MONDO:i2s)
- Orphanet:319705 (MONDO:equivalentObsolete)
- ICD9:332 (EFO:0002508)
- OMIMPS:168600 (MONDO:equivalentTo)
- EFO:0002508 (MONDO:equivalentTo)
- SCTID:49049000 (MONDO:equivalentTo)
- NCIT:C26845 (MONDO:equivalentTo)
rare, orphanet_rare, clingen
https://omim.org/phenotypicSeries/PS168600
http://purl.obolibrary.org/obo/DOID_14330
http://linkedlifedata.com/resource/umls/id/C0030567
http://identifiers.org/mesh/D010300
http://purl.obolibrary.org/obo/NCIT_C26845
http://identifiers.org/snomedct/49049000