A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy. [ NCIT:C3879 ]
Synonyms: parafollicular cell carcinoma medullary carcinoma of thyroid gland C cell carcinoma medullary carcinoma thyroid gland medullary carcinoma ultimobranchial thyroid tumor medullary carcinoma of the thyroid gland carcinoma of parafollicular cell thyroid medullary carcinoma thyroid gland medullary cancer medullary thyroid gland carcinoma thyroid gland neuroendocrine carcinoma medullary thyroid cancer carcinoma, C-cell, malignant medullary carcinoma of thyroid medullary carcinoma of the thyroid medullary thyroid carcinoma MTC ultimobranchial thyroid tumour
Term information
- icd11.foundation:578519098 (https://orcid.org/0000-0002-4142-7153)
- NCIT:C3879 (MONDO:equivalentTo)
- MedDRA:10027101 (Orphanet:1332/e)
- ONCOTREE:THME (MONDO:equivalentTo)
- HP:0002865 (MONDO:otherHierarchy)
- SCTID:255032005 (MONDO:equivalentTo)
- DOID:3973 (MONDO:equivalentTo)
- MEDGEN:66772 (MONDO:equivalentTo)
- NANDO:2201054 (https://orcid.org/0000-0003-0011-764X)
- GARD:7004 (MONDO:GARD)
- Orphanet:1332 (MONDO:equivalentTo)
- UMLS:C0238462 (MONDO:equivalentTo)
ordo_disorder, gard_rare, otar, rare, orphanet_rare
http://linkedlifedata.com/resource/umls/id/C0238462
http://identifiers.org/medgen/66772
http://purl.obolibrary.org/obo/DOID_3973
http://identifiers.org/snomedct/255032005
http://www.orpha.net/ORDO/Orphanet_1332
http://purl.obolibrary.org/obo/NCIT_C3879
thyroid carcinoma, medullary
thyroid cancer, medullary
THME
medullary thyroid cancer (MTC)