An unusual benign or malignant neoplasm characterized by the presence of neoplastic large polygonal cells with granular, eosinophilic cytoplasm which contains abundant lysosomes. It was originally thought to be a tumor originating from muscle cells and was named granular cell myoblastoma. Subsequent studies have suggested a derivation from Schwann cells. It affects females more often than males and it usually presents as a solitary mass. A minority of patients have multiple tumors. It can arise from many anatomic sites including the posterior pituitary gland, skin, oral cavity, esophagus, stomach, heart, mediastinum, and breast. [ NCIT:C3474 ]
Synonyms: granular cell myoblastoma granular cell tumour (morphologic abnormality) Abrikossoff's tumor granular cell neoplasm granular cell tumor (morphologic abnormality) granular cell nerve sheath tumour Abrikossoff's tumour granular cell tumor Abrikossoff tumor Abrikossoff tumour granular cell schwannoma granular cell nerve sheath tumor
Term information
- EFO:1000284 (MONDO:equivalentTo)
- NCIT:C3474 (MONDO:exact-label-match)
- MEDGEN:88345 (MONDO:equivalentTo)
- GARD:9618 (MONDO:GARD)
- MESH:C535558 (MONDO:equivalentTo)
- MESH:D016586 (MONDO:equivalentTo)
- ICD9:215.9 (MONDO:relatedTo)
- UMLS:C0085167 (MONDO:equivalentTo)
- SCTID:404035005 (MONDO:equivalentTo)
- DOID:2411 (MONDO:equivalentTo)
- ONCOTREE:GCT (MONDO:equivalentTo)
- ICDO:9580/0 (NCIT:C3474)
gard_rare, otar, rare, nord_rare
Editor note: MESH considers this a myoblastoma but we go with NCIT which states nerve sheath origin, consistent with GARD definition; also check ONCOTREE placement
http://identifiers.org/mesh/C535558
http://linkedlifedata.com/resource/umls/id/C0085167
http://purl.obolibrary.org/obo/NCIT_C3474
http://identifiers.org/mesh/D016586
http://purl.obolibrary.org/obo/DOID_2411
http://identifiers.org/medgen/88345
http://identifiers.org/snomedct/404035005
neoplasm of granular cell
granular cell tumour NOS (morphologic abnormality)
granular cell tumor NOS (morphologic abnormality)
Abrikosov’s tumour
Abrikosoff's granulous cell tumor
Abrikosoff's tumor
Abrikosov's tumor
Abrikosoff's granulous cell tumour
Abrikosov’s tumor
giant granulocellular Abrikosov's tumour
malignant variant of Abrikosov's tumor
giant granulocellular Abrikosov's tumor
Abrikosoff's tumour
GCT
malignant variant of Abrikosov's tumour
Abrikosov's tumour