A collection of activated B cells at the center of a secondary follicle, formed after B cells become activated and migrate to the center. [ http://purl.obolibrary.org/obo/CL_tm http://en.wikipedia.org/wiki/Germinal_center https://orcid.org/0000-0002-6601-2165 ]
Synonyms: reaction center of follicle central zone of follice
Term information
- NCIT:C13337
- BTO:0003671
- MESH:D018858
- EV:0100051
- Wikipedia:Germinal_center
human_reference_atlas
A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation.[GO]