One of the two embryological structures that give rise to the kidney (the other is the ureteric bud). The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.[WP]. Metanephric mesenchyme is the tissue made up of loosely connected mesenchymal cells in the metanephros[GO]. [ http://amigo.geneontology.org/amigo/term/GO:0072075 http://en.wikipedia.org/wiki/Metanephric_blastema ]
Synonyms: metanephric blastema metanephrogenic mesenchyme metanephric mesoderm metanephros associated mesenchyme
Term information
- VHOG:0000540
- Wikipedia:Metanephric_blastema
- EHDAA:4041
- EHDAA:5915
- EMAPA:17375
- EHDAA2:0004062
- SCTID:361529008
- EHDAA:5021
pheno_slim
Genes: The positional specification of the metanephrogenic mesenchyme is negatively regulated by Foxc1 and Foxc2. Next the permanent kidney forming metanephrogenic mesenchyme is specified by Hox11 genes. The competence to respond to ureteric bud inducers is regulated by WT1. GDNF secretion restricted to posterior region by Robo2 and Sprouty1. The receptors for GDNF are synthesized in the nephric ducts and later in ureteric buds [ISBN:9780878932504 "Developmental Biology"]