A cell type that can give rise to basophil and mast cells. This cell is CD34-positive, CD117-positive, CD125-positive, FceRIa-negative, and T1/ST2-negative, and expresses Gata-1, Gata-2, C/EBPa [ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1312421 GOC:dsd GOC:tfm GOC:ak ]
Synonyms: BMCP
Term information
cellxgene_subset
There may be an intermediate cell type. These cells also CD13-positive, CD16-positive, CD32-positive, and integrin beta 7-positive. Transcription factors: GATA1-positive, MCP-1-positive, mitf-positive, PU.1-positive, and CEBP/a-low.
Term relations
- myeloid lineage restricted progenitor cell and has part some CCAAT/enhancer-binding protein alpha and has part some erythroid transcription factor and has part some endothelial transcription factor GATA-2 and lacks_plasma_membrane_part some high affinity immunoglobulin epsilon receptor subunit alpha and lacks_plasma_membrane_part some transmembrane emp24 domain-containing protein 1 and has plasma membrane part some interleukin-5 receptor subunit alpha and capable of some basophil differentiation and capable of some mast cell differentiation
- granulocytopoietic cell
- myeloid cell
- myeloid lineage restricted progenitor cell
- capable of some basophil differentiation
- lacks_plasma_membrane_part some transmembrane emp24 domain-containing protein 1
- capable of some mast cell differentiation
- has part some CCAAT/enhancer-binding protein alpha
- has part some erythroid transcription factor
- has plasma membrane part some interleukin-5 receptor subunit alpha
- lacks_plasma_membrane_part some high affinity immunoglobulin epsilon receptor subunit alpha
- develops from some granulocyte monocyte progenitor cell
- has part some endothelial transcription factor GATA-2