An activated mature (naive or memory) B cell that is secreting immunoglobulin, typified by being CD27-positive, CD38-positive, CD138-negative. [ GOC:dsd https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673126 http://purl.obolibrary.org/obo/go/references/0000031 GOC:msz GOC:tfm ]
Synonyms: CD27-positive, CD38-positive, CD20-negative B cell
Term information
- FMA:84371
cellxgene_subset, human_reference_atlas
This cell type is compatible with the HIPC Lyoplate markers for 'plasmablast'. Plasmablasts are also reportedly CD48-positive, CD63-positive, CD229-positive, CD270-positive, CD319-positive, CD352-positive, CD361-positive, and IgD-negative.
Term relations
- mature B cell and lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1 and lacks_plasma_membrane_part some syndecan-1 and produces some immunoglobulin complex, circulating and has high plasma membrane amount some ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 and has high plasma membrane amount some CD27 molecule
- antibody secreting cell
- mature B cell
- has high plasma membrane amount some ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
- lacks_plasma_membrane_part some syndecan-1
- lacks_plasma_membrane_part some membrane-spanning 4-domains subfamily A member 1
- has high plasma membrane amount some CD27 molecule
- develops from some mature B cell