A mature B cell that is located in the marginal zone of the spleen with the phenotype CD23-negative and CD21-positive and expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL. This cell type is also described as being CD19-positive, B220-positive, IgM-high, AA4-negative, CD35-high. [ https://www.worldcat.org/search?q=bn%3A0781735149 GOC:dsd GOC:add http://www.ncbi.nlm.nih.gov/pubmed/10933592 http://www.ncbi.nlm.nih.gov/pubmed/20933013 http://en.wikipedia.org/wiki/Marginal-zone_B_cell ]
Synonyms: marginal zone of spleen B cell B cell of marginal zone of spleen
Term information
human_reference_atlas
MZ B cells are reportedly CD1-positive (mice), CD20-positive, CD48-positive, CD84-positive, CD150-positive, CD229-positive, and CD352-positive.
marginal zone B-cell
MZ B lymphocyte
MZ B cell
MZ B-lymphocyte
marginal zone B lymphocyte
marginal zone B-lymphocyte
marginal zone B cell
MZ B-cell
Term relations
- mature B cell and part of some marginal zone of spleen and lacks_plasma_membrane_part some low affinity immunoglobulin epsilon Fc receptor and lacks_plasma_membrane_part some complement component C1q receptor and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and has plasma membrane part some complement receptor type 2 and capable of some defense response to bacterium and has high plasma membrane amount some IgM immunoglobulin complex
- splenocyte
- mature B cell
- lacks_plasma_membrane_part some low affinity immunoglobulin epsilon Fc receptor
- has high plasma membrane amount some IgM immunoglobulin complex
- capable of some defense response to bacterium
- has plasma membrane part some complement receptor type 2
- lacks_plasma_membrane_part some complement component C1q receptor
- has plasma membrane part some membrane-spanning 4-domains subfamily A member 1
- part of some marginal zone of spleen