A rapidly cycling mature B cell that has distinct phenotypic characteristics and is involved in T-dependent immune responses and located typically in the germinal centers of lymph nodes. This cell type expresses Ly77 after activation. [ http://www.ncbi.nlm.nih.gov/pubmed/19447676 http://www.ncbi.nlm.nih.gov/pubmed/20933013 GOC:dsd GOC:tfm GOC:add https://www.worldcat.org/search?q=bn%3A0781735149 ]
Synonyms: germinal center B-lymphocyte germinal center B lymphocyte GC B-lymphocyte GC B cell GC B-cell germinal center B-cell GC B lymphocyte
Term information
cellxgene_subset, human_reference_atlas
Germinal center B cells are also reportedly CD10-positive, CD19-positive, CD20-positive, CD38-positive, CD44-low, CD45-positive, CD48-positive, CD95-positive, CD352-positive, and HLA-DR-positive. Transcription factors: BCL6-positive, Ets1-positive, IRF8-positive, MTA3-positive, OBF1-positive, PAX5-positive, SpiB-positive, and STAT3-positive.
Term relations
- mature B cell and part of some secondary nodular lymphoid tissue and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1