A progenitor cell of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but not yet fully committed to the B cell lineage until the expression of PAX5 occurs. [ GOC:dsd http://www.ncbi.nlm.nih.gov/pubmed/12633665 http://www.ncbi.nlm.nih.gov/pubmed/18432934 http://www.ncbi.nlm.nih.gov/pubmed/16551251 https://www.worldcat.org/search?q=bn%3A0781735149 GOC:add ]
Synonyms: pro-B lymphocyte progenitor B lymphocyte pro-B-cell pro-B-lymphocyte progenitor B cell progenitor B-lymphocyte progenitor B-cell
Term information
cellxgene_subset, human_reference_atlas
Human pro-B cells are reportedly CD10-positive, CD22-positive, CD34-positive, CD38-positive, CD45-low, CD48-positive, CD79a-positive, CD127-positive, CD184-positive, RAG-positive, TdT-positive, Vpre-B-positive, pre-BCR-negative, IgD-negative, and IgM-negative. Transcription factors expressed: Pax5-positive, EBF-positive, E2A-negative, Ikaros-negative, and PU.1-negative.
Term relations
- lymphoid lineage restricted progenitor cell and has part some paired box protein PAX-5 and has part some DNA nucleotidylexotransferase and participates in some immunoglobulin V(D)J recombination
- lymphoid lineage restricted progenitor cell
- has part some paired box protein PAX-5
- participates in some immunoglobulin V(D)J recombination
- has part some DNA nucleotidylexotransferase
- develops from some common lymphoid progenitor