A thymocyte that has the phenotype CD4-negative, CD8-negative, CD44-negative, and CD25-positive and expressing the T cell receptor beta-chain in complex with the pre-T cell receptor alpha chain. [ https://www.worldcat.org/search?q=bn%3A0781735149 GOC:tfm GOC:add http://purl.obolibrary.org/obo/go/references/0000031 ]
Synonyms: TN3 thymocyte preT.DN3.Th DN3 cell double negative 3 TN3 cell DN3 alpha-beta immature T-lymphocyte DN3 immature T cell DN3 alpha-beta immature T-cell DN3 alpha-beta immature T lymphocyte
Term information
cellxgene_subset
There is growing evidence that molecular markers characterizing double negative thymocytes are different across species, especially in mouse versus human thymus. If in doubt, please consider using CL:0002489 'double negative thymocyte'.
Term relations
- thymocyte and lacks_plasma_membrane_part some CD4 molecule and lacks_plasma_membrane_part some CD44 molecule and lacks_plasma_membrane_part some T cell receptor co-receptor CD8 and has plasma membrane part some pre-T cell receptor complex and has plasma membrane part some interleukin-2 receptor subunit alpha
- thymocyte
- double negative thymocyte
- develops from some DN2 thymocyte
- lacks_plasma_membrane_part some CD44 molecule
- has plasma membrane part some interleukin-2 receptor subunit alpha
- has plasma membrane part some pre-T cell receptor complex