A memory B cell is a mature B cell that is long-lived, readily activated upon re-encounter of its antigenic determinant, and has been selected for expression of higher affinity immunoglobulin. This cell type has the phenotype CD19-positive, CD20-positive, MHC Class II-positive, and CD138-negative. [ GOC:add GOC:dsd http://www.ncbi.nlm.nih.gov/pubmed/20081059 GOC:rhs http://purl.obolibrary.org/obo/go/references/0000031 http://en.wikipedia.org/wiki/Memory_B_cell https://www.worldcat.org/search?q=bn%3A0781735149 http://www.ncbi.nlm.nih.gov/pubmed/20839338 ]
Synonyms: memory B-lymphocyte memory B lymphocyte memory B-cell
Term information
cellxgene_subset, human_reference_atlas
Memory B-cells are also reportedly CD5-negative, CD10-negative, CD21-positive, CD22-positive, CD23-negative, CD24-positive, CD25-positive, CD27-positive, CD34-negative, CD38-negative, CD40-positive, CD43-negative, CD44-positive, CD45-positive, CD53-positive, CD80-negative, CD81-negative, CD86-positive, and CD196/CCR6-positive.
Term relations
- mature B cell and lacks_plasma_membrane_part some syndecan-1 and has plasma membrane part some MHC class II protein complex and has plasma membrane part some membrane-spanning 4-domains subfamily A member 1 and output of some B cell affinity maturation