A cell that is found in the perisinusoidal space of the liver that is capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components that can contribute to liver fibrosis. This activated state has a myofibroblast-like phenotype, though it's not clear in the literature if this is terminally differentiated. This cell type comprises approximately 8-15% of total cells in the liver. [ MESH:D055166 http://en.wikipedia.org/wiki/Hepatic_stellate_cell http://www.ncbi.nlm.nih.gov/pubmed/18222966 http://www.ncbi.nlm.nih.gov/pubmed/12808230 GOC:dsd http://www.ncbi.nlm.nih.gov/pubmed/9302568 http://www.ncbi.nlm.nih.gov/pubmed/17239632 ]
Synonyms: hepatic perisinusoidal cell Ito cell perisinusoidal cell
Term information
- BTO:0002741
- CALOHA:TS-0452
- FMA:67763
cellxgene_subset, human_reference_atlas
Hepatic stellate cells are CD271-positive, desmin-positive, DDR-2-positive, GFAP-positive, synamin-positive, synaptophysin-positive, vimentin-positive, They are capable of producing angiotensin II, fibronectin, laminin, MMP-1, MMP-2, MMP-3, MMP-9, MMP-11, TGF-beta1, TIMP-1, TIMP-2, type I collagen, type III collagen, type IV collagen, and type VI collagen.
Term relations
- connective tissue cell and part of some liver and has plasma membrane part some glial fibrillary acidic protein