A hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages. These cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1. [ GOC:amm http://purl.obolibrary.org/obo/go/references/0000031 http://www.ncbi.nlm.nih.gov/pubmed/16551251 MESH:D055014 GOC:dsd https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213186 http://www.ncbi.nlm.nih.gov/pubmed/16647566 https://www.worldcat.org/search?q=bn%3A0721601464 http://en.wikipedia.org/wiki/CFU-GM GOC:tfm http://www.copewithcytokines.de https://www.ncbi.nlm.nih.gov/pmc/articles/PMC548021 ]
Synonyms: colony forming unit granulocyte macrophage granulocyte/monocyte progenitor granulocyte/monocyte precursor granulocyte-macrophage progenitor
Term information
cellxgene_subset, human_reference_atlas
Originally described in the dendritic cell ontology (DC_CL:0000042)(PMID:19243617). GMPs are reportedly CD16-positive, CD32-positive, CD34-positive, CD38-positive, CD45RA-positive, CD110-negative, CD117-positive, CD123-positive, and SCA1-negative.
Term relations
- hematopoietic oligopotent progenitor cell and part of some bone marrow and has part some transcription factor PU.1 and has part some CCAAT/enhancer-binding protein alpha and lacks_part some erythroid transcription factor and lacks_part some endothelial transcription factor GATA-2 and has plasma membrane part some interleukin-3 receptor class 2 alpha chain and capable of some macrophage differentiation and capable of some granulocyte differentiation
- bone marrow hematopoietic cell
- hematopoietic oligopotent progenitor cell
- progenitor cell
- myeloid cell
- CD7-negative lymphoid progenitor OR granulocyte monocyte progenitor
- capable of some granulocyte differentiation
- capable of some macrophage differentiation
- has part some transcription factor PU.1
- has plasma membrane part some interleukin-3 receptor class 2 alpha chain
- has part some CCAAT/enhancer-binding protein alpha
- lacks_part some endothelial transcription factor GATA-2
- lacks_part some erythroid transcription factor